CANNABINOIDERGIC REGULATION OF CARDIAC CONTRACTILITY DURING ISCHEMIA/REPERFUSION
Authors studied an impact of selective ligands of cannabinoid (CB) receptors on the contractility of the isolated perfused rat heart during global ischemia and reperfusion. A perfusion by solution containing the selective CB-agonist HU-210 exacerbated a cardiac contractility dysfunction. This cannabinoid decreased the left ventricular developed pressure, the maximal rate of contraction and relaxation of the heart during reperfusion but had no effect on the heart rate and the end diastolic pressure. Negative inotropic effect of HU-210 was transient and disappeared after 5 min reperfusion. The pretreatment with the selective CB1 receptor antagonist SR141716A and the selective CB2 receptor antagonist SR144528 had no effect on the myocardial contractility during reperfusion. In conclusion, the present results indicate that CB receptor stimulation can exacerbate reperfusion contractility dysfunction of the heart. Endogenous cannabinoids are not involved in the development of myocardial contractility dysfunction during ischemia/reperfusion of the heart.
Keywords: cannabinoid receptors, cardiac contractility, ischemia, reperfusion, isolated heart
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Issue: 3, 2009
Rubric: Cardiology and Functional Diagnostics
Pages: 25 — 30
Downloads: 795