ACTIVE PEPTIDE-DIPEPTIDASE A IN TISSUES OF RATS NEYRVNOY SINGLE ACTION NOOTROPICS
The activity of peptidyl-dipeptidazy A in the brain of rats following single fold action piracetam, рhenotropil, noopept after 0.5 hours, 4 hours, 24 hours, 72 ca-meat after injection. In terms of short-term mode of administration used nootropics general trends identified changes in the activity peptidyl-dipeptidazy A: the highest activity was observed in the pituitary gland at 72 hours after injection рhenotropil and the striatum 4 hours after injection of piracetam and noopept. Marker-tion measurable activity of the enzyme studied in rats after a single dose pre-nootropic preparations in the dynamics of observation can serve as one of the key biochemical characterized-tics possible neurochemical mechanism of action.
Keywords: activity peptidildipeptidazy A, nervous tissue of rats, piracetam, fenotropil, noopept, single action
References:
1. Grazhdantseva N. N., Samotrueva M. A., Tyurenkov I. N., Khlebtsova E. B., Berestovitskaya V. M., Vasil’eva O. S. Immunotropnaya aktivnost’ fenotropila i ego kompozitsii s glutaminovoy kislotoy [Immunotropic activity of phenotropil and his compositions with glutamic acid]. Farmatsiya – Farmaceutics, 2010, no. 8, pp. 38–40 (in Russia).
2. Magomedov M. M., Samotrueva M. A., Berestovitskaya V. M., Vasil’eva O. S., Tyurenkov I. N. Vliyaniye proizvodnogo fenotropila RGPU-154 na fagotsitarnuyu aktivnost’ neytrofi lov pri eksperimental’noy depressii [Effect of derivative phenotropil WPC-154 on the phagocytic activity of neutrophils in experimental depression]. Mezhdunarodnyy zhurnal eksperimental’nogo obrazovaniya – International Journal of Experimental Education, 2015, no. 2–2, pp. 178–179 (in Russia).
3. Magomedov M. M., Samotrueva M. A., Tyurenkov I. N., Khlebtsova E. B., Igeysinov N. G. Vliyaniye fenotropila na aktivnost’ katalazy v razlichnykh otdelakh kory golovnogo mozga krys linii Wistar v usloviyakh eksperimental’nogo immunnogo stressa [Infl uence of phenotropil on catalase activity in different parts of the cerebral cortex of Wistar rats in experimental immune stress]. Mezhdunarodnyy zhurnal prikladnykh i fundamental’nykh issledovaniy – International Magazine of Applied and Fundamental Research, 2011, no. 5, pp. 77–78 (in Russia).
4. Samotrueva M. A., Tyurenkov I. N., Teplyy D. L., Luzhnova S. A., Magomedov M. M. Vyrazhennost’ immunokorrigiruyushchikh svoystv fenotropila pri primenenii v razlichnye sroki otnositel’no induktsii immunosupressii [Intensity of phenotropil immunocorrective properties when used in different periods with respect to induction immunosuppression]. Meditsinskaya immunologiya – Medical Immunology, 2009, no. 6, pp. 567–570 (in Russia).
5. Samotrueva M. A., Tyurenkov I. N., Teplyy D. L., Serezhnikova T. K., Magomedov M. M., Priluchnyy S. V. Immunomoduliruyushchiye effekty fenotropila i ego organicheskikh soley [Immunomodulatory effects of phenotropil and its organic salts]. Astrahanskiy meditsinskiy zhurnal – Astrakhan Medical Journal, 2011, no. 1, pp. 100–103 (in Russia).
6. Samotrueva M. A., Tyurenkov I. N., Teplyy D. L., Serezhnikova T. K., Khlebtsova E. B. Psikhoimmunomoduliruyushcheye deystviye fenotropila u immunostressirovannykh zhivotnykh [Psycho immunomodulatory effects of phenotropil of immune stressed animals]. Bulleten’ eksperimental’noy biologii i meditsiny – Bulletin of Experimental Biology and Medicine, 2011, no. 1, pp. 59–62 (in Russia).
7. Tyurenkov I. N., Bagmetova V. V., Shishkina A. V., Berestovitskaya V. M., Vasil’eva O. S., Ostroglyadov E. S. Gendernye otlichiya v deystvii fenotropila i ego strukturnogo analoga – soedineniya RGPU-95 na trevozhno-depressivnoye povedeniye zhivotnykh [Gender differences in phenotropil effects and its structural analogs-compounds WPC-95 on anxiety-depressive behavior of animals]. Eksperimental’naya i klinicheskaya farmakologiya – Experimental and Clinical Pharmacology, 2010, vol. 73, no. 11, pp. 10–14 (in Russia).
8. Tyurenkov I. N., Galimzyanov H. M., Teplyy D. L., Samotrueva M. A., Luzhnova S. A. Eksperimental’noye izucheniye immunokorrigiruyushchikh svoystv fenotropila v aspekte “doza-effekt” [Experimental study of immunocorrective properties of phenotropil in terms of “dose-response”]. Immunologiya – Immunology, 2009, no. 5, pp. 302–305 (in Russia).
9. Tyurenkov I. N., Samotrueva M. A., Grazhdantseva N. N., Khlebtsova E. B., Berestovitskaya V. M., Vasil’eva O. S. Immunomoduliruyushchiye svoystva kompozitsii fenotropila i glutaminovoy kisloty [Immunomodulatory properties of the composition of phenotropil and glutamic acid]. Biomeditsina – Biomedicine, 2011, no. 3, pp. 63–69 (in Russia).
10. Samotrueva M. A., Tyurenkov I. N., Luzhnova S. A., Magomedov M. M., Kuleshevskaya N. R., Serezhnikova T. K. Experimental learning of doserelated infl uence of phenotropil on humoral link of immunogenesis. European Journal of Natural History, 2010, no. 3, pp. 61–62.
11. Eliseeva Yu. E., Kugaevskaya E. V. Struktura i fi ziologicheskoye znachenyie domenov angiotenzinprevrashchayushchego fermenta [Structure and physiological signifi cance of angiotensin-converting enzyme domains]. Biomeditsinskaya khimiya, 2009, vol. 55, no. 4, pp. 397–414 (in Russia).
12. Khloponin D. P., Krotova Yu. N., Ivanov I. V. Osobennosti farmakologii sovremennykh ingibitorov angiotenzinprevrashchayushchego fermenta (na primere moeksiprila) [Pharmacology of modern angiotensin converting enzyme inhibitors (for example moexipril)]. Kardiovaskulyarnaya terapiya i profi laktika – Cardiovascular Therapy and Prevention, 2007, vol. 6, no. 5, pp. 99–106 (in Russia).
13. Zhu Yi Zhun, Lee How Sung. Angiotensin converting enzyme inhibition after myocardial infarction. Asian Cardiovasc. Thorac. Ann., 2000, vol. 8, pp. 85–90.
14. Rukovodstvo po laboratornym zhivotnym i al’ternativnym modelyam v biomeditsinskikh issledovaniyakh [Guidance on laboratory animals and alternative models in biomedical research]. Eds. N. N. Karkischenko, S. V. Grachev. Moscow, Profi l’-2S Publ., 2010. 358 p. (in Russia).
15. Nazarova G. A., Zolotov N. N., Krupina N. A., Krayneva N. A., Garibova T. L., Voronina T. A. Izmeneniye aktivnosti prolinspetsifi cheskikh peptidaz pri eksperimental’nom modelirovanii retrogradnoy amnezii [Changes in proline peptidase activity in experimental modeling of retrograde amnesia]. Eksperimental’naya i klinicheskaya farmakologiya – Experimental and Clinical Pharmacology, 2007, vol. 70, no. 6, pp. 6–8 (in Russia).
16. Belousov Yu. B., Mukhina M. A. Fenotropil – nootropnyy preparat novogo pokoleniya [Phenotropil – nootropics of new generation]. Kachestvennaya klinicheskaya praktika – Good clinical practice, 2005, no. 3, pp. 1–9 (in Russia).
17. Kovalenko L. P., Smol’nikova N. M., Alekseeva S. V., Nemova E. P., Sorokina A. V., Miramedova M. G., Kurapova S. P., Sidorina E. I., Kulakova A. V., Daugel’-Dauge N. O. Doklinicheskoye izucheniye toksichnosti noopepta [Preclinical toxicity studies of noopept]. Eksperimental’naya i klinicheskaya farmakologiya – Experimental and Clinical Pharmacology, 2002, vol. 65, no. 1, pp. 62–64 (in Russia).
18. Hurst P. L., Lovell-Smith C. J. Optimized assay for serum angiotensin-converting enzyme activity. Clin. Chem., 1981, vol. 27, pp. 2048–2052.
19. Lowry O. H., Rosebrought N. J., Farr A. G., Randall R. J. Protein measurement with the Folin phenol reagent. J. Biol. Chem., 1951, vol. 193, no. 1, pp. 265–275.
20. Lasukova O. V., Maslov L. N., Krylatov A. V., Lasukova T. V. Vliyanie agonistov kannabinoidnyh receptorov na rezistentnost’ miokarda k deystviyu ishemii i reperfuzii [Effect of cannabinoid receptor agonists on the cardiac resistance to impact of ischemia and reperfusion]. Vestnik Tomskogo gosudarstvennogo pedagogicheskogo universiteta – TSPU Bulletin, 2012, vol. 7 (122), pp. 116–121 (in Russia).
21. Nizkodubova S. V., Lasukova T. V. Vliyaniye ul’tradispersnykh poroshkov p’ezokeramiki na nekotorye pokazateli krovi krys pri dlitel’nom khronicheskom vozdeystvii [Effect of ultrafi ne powders of piezoelectric ceramics for some blood parameters in rats during their long-term chronic exposure]. Vestnik Tomskogo gosudarstvennogo pedagogicheskogo universiteta – TSPU Bulletin, 2012, vol 7 (122), pp. 122–128 (in Russia).
22. Nizkodubova S. V., Lasukova T. V., Legostin S. A. Primeneniye lipidov sapropelya dlya korrektsii narusheniy metabolizma pecheni krys pri toksiko-khimicheskom gepatite [Correction of energy metabolism impraiments in tetrachlormethane-poisoned rat liver tissue by means of sapropel lipids]. Vestnik Tomskogo gosudarstvennogo pedagogicheskogo universiteta – TSPU Bulletin, 2013, vol. 8 (136), pp. 94–99 (in Russia).
( 898.68 kB ) 
( 882.56 kB )
Issue: 11, 2015
Series of issue: Issue 11
Rubric: BIOLOGY
Pages: 154 — 160
Downloads: 948