COMPARATIVE STUDY OF THE EFFECT OF LIPOSOMES WITH VARIOUS ANTIOXIDANTS UPON THE DEGREE OF HEMOLYSIS AND SHAPE OF THE ERYTHROCYTE WITH HYPOCHLORITE-INDUCED PEROXIDE HAEMOLYSIS

Mukhamadiyarov Rinat Avkhadiyevich, Borisov Vadim Vladimirovich, Toropova Yana Gennadyevna, Bogdanov Maksim Vladimirovich, Lakhmotkina Ekaterina Vasilyevna

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In this paper the authors investigate the extent of peroxide haemolysis, contents of malonic dialdehyde and morphology of human erythrocytes under the infl uence of sodium hypochlorite after incubation with liposomes of different composition. There is an effect of “empty” liposomes and liposomes containing in the structure ±-tocopherol, and dihydroquercetin emoksipin. It is shown that all types of liposomes reduce the degree of hemolysis, the accumulation of malonic dialdehyde and inhibit transformation of erythrocytes. All investigated characteristics of the studied liposomes exhibit a pronounced membrane-stabilizing effect on the peroxide hemolysis of erythrocytes.

Keywords: liposomes, hemolysis, ±-tocopherol, dihydroquercetin, emoksipin

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Issue: 8, 2012

Pages: 179 — 186

Downloads: 924