EFFECT OF CANNABINOID RECEPTOR AGONISTS ON THE CARDIAC RESISTANCE TO IMPACT OF ISCHEMIA AND REPERFUSION

Lasukova Olga Vladimirovna, Maslov Leonid Nikolaevich, Krylatov Andrey Vladimirovich, Lasukova Tatyana Viktorovna

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In experiments with isolated perfused rat heart it was investigated cardioprotective effect of the selective and the nonselective cannabinoid receptor agonists during ischaemia and reperfusion at the final concentration of 0.1 and 1.0 mM. It was established that the CB1 agonist ACPA, the CB1- and CB2-receptor agonist HU-210 and the CB1- and CB2-receptor agonist СР 55,940 exhibit cardioprotective effect. The selective CB2-agonist JWH133 and the CB1- and CB2-receptor agonists anandamide and methanandamide did not exhibit cytoprotective effect. Cardioprotective effect HU-210 is depended on the activation of CB1-cannabinoid receptor.

Keywords: Cannabinoid receptors, isolated heart

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Issue: 7, 2012

Pages: 116 — 121

Downloads: 935