OPIOID SYSTEM AND ADAPTATION TO HYPOXIA

Lasukova Tatyana Viktorovna, Nizkodubova Svetlana Vasilyevna, Tayurskaya Aleksandra Sergeyevna

Information About Author:

The paper deals with the analysis of opioid receptors, their endogenous and synthetic agonists in the formation of resistance to acute hypoxia. The article proves that stimulation of opioid receptors is normally accompanied by a neuroprotective effect in acute hypoxia. It also studies the role of different types of opioid receptors in the implementation of the adaptation protective effect to hypoxia. Mechanisms opioids activity, the role of cAMP, cGMP, nitric oxide, inositol triphosphate, K+ - and Ca2 + -channels in implementation of agonists effects of opioid receptors are analysed. Opioidergic mechanisms of the reactions that increase the resistance to hypoxia are described.

Keywords: opioid receptors, opioid system, КАТР-channels, cAMP, cGMP, inositoltriphosphate, nitric oxide, hypoxia, adaptation.

( 343.9 kB ) ( 331.98 kB )

Issue: 8, 2011

Series of issue: Issue 8

Pages: 109 — 114

Downloads: 988