PARAMETERS OF PROGRAMMED DEATH OF LYMPHOCYTES AND NEUTROPHILS IN PERSONS WITH ALCOHOL INTOXICATION IN DYNAMIC OF THERAPY PREPARATION WITH ANTIOXIDANT PROPERTIES
Objective of this study was researching the apoptosis of lymphocytes and neutrophils in alcoholic patients in dynamic of the therapy with preparation cytophlavin. Level of apoptosis in lymphocytes and neutrophils on receptor and cellular levels statistically significant increase in group of persons with alcohol intoxication, compared with healthy donors. Therapy with cytophlavin resulted in positive dynamic expressing receptors CD5 on lymphocytes of persons with alcohol intoxication. Trend toward normalization of number of neutrophils and lymphocytes with morphological signs of apoptosis has been noticed. During application of cytophlavin in patients with alcoholism decrease of concentration of cortisol in serum of blood was observed.
Keywords: apoptosis, alcoholism, cytophlavin, neutrophils , lymphocytes
References:
1. Bokhan N.A. Molecular mechanisms of influence of ethanol and its metabolites on erythrocytes in vitro and in vivo / N.A. Bokhan,V.D. Prokopyeva. –Tomsk, 2004. – 166 p.
2. Halliwell D. B. Free Radicals in Biology and medcine / D. B. Halliwell, J. M. Gutteridg // Oxford University Press – 1999. – P.936
3. Freund G. Apoptosis and gene expression: perspectives on alcoholinduced brain damage / G. Freund // Alcohol – 1994 – Vol.11 – P. 385-387.
4. Olney J.W. Glutamate signaling and the fetal alcohol syndrome / J.W. Olney, D.F. Wozniak, V. Jevtovic-Todorovic// Ment. Retard. Dev. Disabil. Res. Rev. – 2001. - №7. – Р. 267 – 275.
5. Adinoff B. Disturbances of the stress response: the role of the HPA axis during alcohol withdrawal and abstinence / B. Adinoff, A. Iranmanesh, J. Veldhuis, L. Fisher // Alcohol Health Res World – 1998. – Vol. 22 №1 – P. 67-72.
6.Adinoff R. Increased salivary cortizol concentrations during chronic alcohol concentrations in a naturalistic clinical sample of men / R. Adinoff, K. Ruether, S.Krebaum, M. Williams //Alcohol Clin Exp Res. – 2003. – Vol.27. – P.1420-1427.
7. Kochetkov Ya. A. Depression and hypothalamic-pituitary-adrenal system: new strategies of study / Ya. A. Kochetkov // Modern problems of psychiatric endocrinology. – 2004. – V. 5. – P. 161-174.
8. Antioxidant and neurotrophic action of cytophlavin in chronic cerebrovascular diseases / Suslina Z.A., Tanashyan M.M., Smirnova I.N. et al. // Bulletin of Siberian State Medical Academy. – 2002. - № 3. – P. 110-114.
9. Application of cytophlavin in toxic and posthypoxic encephalopathy: Manual for doctors / Livanov G.A., Batotsyrenov B.V., Glushkov S.I. et al. – Saint-Petersburg., 2004. – 44 p.
( 1.82 MB ) 
( 1.31 MB )
Issue: 3, 2009
Rubric: Pathophysiology
Pages: 59 — 62
Downloads: 1026