PARAMETERS OF ENDOGENOUS INTOXICATION IN THE SERUM OF PATIENTS WITH SCHIZOPHRENIA DURING THE LONG-TERM ANTIPSYCHOTIC TREATMENT
The main method of treating schizophrenia is the use of antipsychotic medication. The aim of this study was to investigate the parameters of endogenous intoxication in the serum of patients with schizophrenia during the longterm antipsychotic therapy. We demonstrated a significant change in the spectrum of middle mass molecules in the blood serum in patients with drug-induced side effects (tardive dyskinesia), which was manifested in higher rates of toxic and nuclear fractions.
Keywords: middle mass molecules, schizophrenia, tardive dyskinesia, antipsychotic therapy, endogenous intoxication
References:
1. Lebedeva G. G., Isaeva E. R., Stepanova A. V. Cognitive defi cits in paranoid schizophrenia and schizotypal disorder: a comparative study of cognitive impairment. Tomsk State Pedagogical University Bulletin, 2013, no. 5, pp. 155–160 (in Russian).
2. Krasnov V. N., Gurovich I. Ja., Mosolov S. N., Shmukler A. B. Standards of care for patients with schizophrenia, Moscow, 2006. 54 p. (in Russian).
3. Boskovic M., Vovk T., Plesnicar B.K., Grabnar I. Oxidative stress in schizophrenia. Current Neuropharmacology, 2011, no. 9, pp. 301–312.
4. Smirnova L. P., Krotenko N. V., Krotenko N. M, Loginov V. N., Duhan M. V., Ivanova S. A., Mal’ceva Ju. L. Activity of antioxidant enzymes in erythrocytes with mental and neurological disorders. Siberian Herald of Psychiatry and Addiction Psychiatry, 2008, №. 1, pp. 133–135 (in Russian).
5. Kropp S., Kern V., Lange K. et al. Oxidative stress during treatment with fi rst- and second-generation antipsychotics. J. Neuropsychiatry Clin. Neurosci., 2005, vol. 17, pp. 227–231.
6. Ivanova S. A., Fedorenko O. Ju., Smirnova L. P., Semke A. V. The search for biomarkers and the development of pharmacogenetic approaches to personalized treatment of patients with schizophrenia. Siberian Herald of Psychiatry and Addiction Psychiatry, 2013, no. 1, pp. 12–16 (in Russian).
7. Galecki P., Pietras T., Florkowki A. Pro- and antioxidant processes in schizophrenics with tardive dyskinesia. Psychiatr. Pol., 2005, vol. 39, no. 6, pp. 1131–1141.
8. Uzbekov M. G. Endotoxemia as an integral component of the pathogenesis of mental disorders. Siberian Herald of Psychiatry and Addiction Psychiatry, 2008, no. 1, pp. 26–30 (in Russian).
9. Rubcov G. K. Complete application of model biological systems for assessment of oxidative modifi cation of proteins in the pool of average weight molecules. Tomsk State Pedagogical University Bulletin, 2013, no. 8, pp. 81–90 (in Russian).
10. Ivanova S. A., Alifi rova V. M., Lebedeva V. F., Krotenko N. V. Clinical and diagnostic value of the average molecular weight in patients with mental and neurological disorders: A guide for physicians. Tomsk, 2010. 32 p. (in Russian).
11. Tsai G., Goff D. C., Chang R. W. et al. Markers of Glutamatergic Neurotransmission and Oxidative Stress Associated With Tardive Dyskinesia. Am. J. Psychiatry, 1998, no. 55 (9), pp. 1207–1213.
12. Andreassen O. A., Jorgensen H. A. Neurotoxicity associated with neuroleptic-induced oral dyskinesias in rats. Implications for tardive dyskinesia? Progress in Neurobiology, 2000., no. 61, pp. 525–541.
13. Al Hadithy A. F., Ivanova S. A., Pechlivanoglou P. et al. Missense polymorphisms in three oxidative-stress enzymes (GSTP1, SOD2, and GPX1) and dyskinesias in Russian psychiatric inpatients from Siberia. Human Psychopharmacology, 2010, vol. 25, no. 1, pp. 84–91.
14. Lohr J. B., Kuczenski R, Niculescu A. B. Oxidative mechanisms and tardive dyskinesia. CNS Drugs, 2003, 17 (1), pp. 47–62.
15. Shchigoreva Yu. G., Boyko A. S., Krotenko N. M., Smirnova L. P., Kornetova E. G., Semke A. V., Ivanova S. A. Glutathione as a criterion for risk prediction of drug-induced tardive dyskinesia in patients with schizophrenia. Siberian Herald of Psychiatry and Addiction Psychiatry, 2012, no. 6 (75), pp. 75–78 (in Russian).
( 474.73 kB ) 
( 461.08 kB )
Issue: 11, 2013
Series of issue: Issue 11
Rubric: MEDICOPSYCHOLOGY
Pages: 75 — 80
Downloads: 592