ОПИОИДНАЯ СИСТЕМА И АДАПТАЦИЯ К ГИПОКСИИ
Обзор посвящен анализу роли опиодных рецепторов, их эндогенных и синтетических агонистов в формировании устойчивости организма к действию острой гипоксии. Приводятся данные о том, что стимуляция опиоидных рецепторов сопровождается нейропротекторным эффектом при острой гипоксии. Рассматривается роль различных типов опиоидных рецепторов в реализации защитного действия адаптации к гипоксии. Анализируются сведения о механизмах действия опиоидов, роли цАМФ, цГМФ, оксида азота, инозитолтрифосфата, К+ - и Са2+ - каналов в реализации эффектов агонистов опиоидных рецепторов. Обсуждаются опиоидергические механизмы, обеспечивающие повышенную устойчивость сердца к последствиям острой кислородной недостаточности.
Ключевые слова: опиоидные рецепторы, опиоидная система, КАТР-каналы, цАМФ, цГМФ, инозитолтрифосфат, оксид азота, гипоксия, адаптация
Библиография:
1. Dhawan B. N., Cesselin F., Raghubir R., Reisine T., Bradley P. B., Portoghese P. S. International union of pharmacology. XII. Classification of opioid receptors // Pharmacol. Rev. 1996. V. 48. № 4. Р. 567–592.
2. Paterson P., Dumont M., Belichard P. et al. Increased preproenkephalin A gene expression in the rat heart after induction of a myocadial infarction // Biochem. Cell. Biol. 1992. V. 70. Р. 593–598.
3. Levac B. A., O’Dowd B. F., George S. R. Oligomerization of opioid receptors: generation of novel signaling units // Curr. Opin. Pharmacol. 2002. V. 2. № 1. P. 76–81.
4. Elde R. Distribution of neuropeptide receptors. New views of peptidergic neurotransmission made possible by antibodies to opioid receptors // Ann. NY Acad. Sci. 1995. V. 757. P. 390–404.
5. Minami M. Molecular biology of the opioid receptors: Structures functions and distributions // Neurosci. Res. 1995. V. 23. P. 121–145.
6. Xiao R. P., Pepe S., Spurgeon H. A. et al. Opioid peptide receptor stimulation reverses b-adrenergic effects in rat heart cells // Am. J. Physiol. 1997. V. 272. Р. 797–805.
7. Zhang W.-M., Jin W.-Q., Wong T. M. Multiplicity of kappa opioid receptor binding in the rat cardiac sarcolemma // J. Mol. Cell. Cardiol. 1996. V. 28. Р. 1547–1554.
8. Brown D. R. Delta-opioid receptor mRNA еxpression and immunogistochemical localization in porcine ileum // Dig. Dis. Sci. 1998. V. 43. P. 1402–1410.
9. Eguchi M. Recent advances in selective opioid receptor agonists and antagonists // Medic. Res. Rev. 2004. V. 24. № 2. P. 182–212.
10. Ventura C., Guarnieri C., Vaona I., Campana G., Pintus G., Spampinato S. Dynorphin gene expression and release in the myocardial cell // J. Biol. Chem. 1994. V. 269. № 7. Р. 5384–5386.
11. Zimlichman R., Gefel D., Eliahou H., Matas Z., Rosen B., Gass S., Ela C. et al. Expression of opioid receptors during heart ontogeny in normotensive and hypertensive rats // Circulation. 1996. V. 93. № 5. Р. 1020–1025.
12. Forman L. J., Hock C. E., Harwell M., Estilow-Isabell S. The results of exposure to immobilization, hemorrhagic shock, cardiac hypertrophy on beta-endorphin in rat cardica tissue // Proc. Soc. Exp. Biol. Med. 1994. V. 206. Р. 124–129.
13. Maslov L. N., Lishmanov Y. B. Changes in opioid peptide level in the heart and blood plasma during acute myocardial ischaemia complicated by ventricular fibrillation // Clin. Exp. Pharm. Physiol. 1995. V. 22. Р. 812–816.
14. Krumius S. A., Faden A. I., Feuerstein G. Opiate binding in rat hearts: modulation of binding after hemorrhagic shock // Biochem. Biophys. Res. Commun. 1985. V. 127. Р. 120–128.
15. Ventura C., Bastagli L., Bernardi P. et al. Opioid receptors in rat cardiac sarcolemma: effect of phenylephrine and isoproterenol // Biochem. Biophys. Acta. 1989. V. 987. Р. 69–74.
16. Cadet P., Bilfinger T. V., Fimiani C. et al. Human vascular and cardiac endothelia express mu opiate receptor transcripts // Endothelium. 2000. № 7. Р. 185–191.
17. Stefano G. B., Hartman A., Bilfinger T. V., Magazine H. I., Liu Y. et al. Presence of the ј3 opiate receptor in endothelial cells // J. Biol. Chem. 1995. V. 270. № 51. Р. 30290–30293.
18. Stefano G. B., Goumon Y., Bilfinger T. V. et al. Basal nitric oxide limits immune, nervous and cardiovascular excitation: Human endothelia express a mu opiate receptor // Progress in Neurobiology. 2000. V. 60. Р. 531–544.
19. Ventura C., Spurgeon H. A., Lоkatta E. G. et al. k- and d- opioid receptor stimulation affects cardiac myocyte function and Ca2+ release from an intacellular pool in myocytes and neurons // Circ. Res. 1992. V. 70. Р. 66–81.
20. Wittert G., Hope P., Pyle D. Tissue distribution of opioid receptor gene expression in the rat // Biochem. Biophys. Res. Commun. 1996. V. 218. Р. 877–881.
21. Law P.Y., Loh H. H. Regulation of opioid receptor activities // J. Pharmacol. Exp. Ther. 1999. V. 289. № 2. P. 607–624.
22. Childers S. R. Opioid receptor-coupled second messenger systems // Life Sci. 1991. V. 48. Р. 1991–2003.
23. Cox B. M. Opioid receptor-G protein interactions: acute and chronic effects of opioids. In: Herz A., Ed. Handbook of Experimental Pharmacology: Opioids I. N. Y.: Springer-Verlag, 1993. Р. 145–188.
24. Ikeda K., Kobayashi T., Ischikawa T. et al. Functional couplings of the ј and the ґ opioid receptors with the G-protein-activated K+ channel // Biochem. Biophys. Res. Comm. 1995. V. 208. Р. 302–308.
25. Niroomand F., Mura R. A., Piacentini L., Kubler W. Opioid receptor agonists activate pertussis toxin-sensitive G proteins and inhibit adenylyl cyclase in canine cardiac sarcolemma // Arch. Pharmacol. 1996. V. 354. Р. 643–649.
26. Aitchinson K. A., Baxter G. F., Awan M. M., Smith R. M., Yellon D. M., Opie L. H. Opposing effects on infarction of delta and kappa opioid receptor activation in the isolated rat heart: implications for ischemic preconditioning // Basic. Res. Cardiol. 2000. V. 95. № 1. Р. 1–10.
27. Lasukova T. V, Maslov L. N., Gorbunov A. S. Opioid receptor agonists operators mimic the phenomenon of ischemic preconditioning of heart: the role of cyclic nucleotides and Ca2 +-ATPase Sarkoplasmatic reticulum // Tomsk State Pedagogical University Bulletin. 2010. Issue 3 (93). P. 64–69.
28. McKenzie F. R., Milligan G. ґ opioid-receptor-mediated inhibition of adenylate cyclase is transduced specifically by the guanine-nucleotidebinding protein Gi2 // Biochem. J. 1990. V. 267. Р. 391–398.
29. Bian J.-S., Wang H.-X., Zhang W.-M., Wong T.-M. Effects of є opioid receptor stimulation in the heart and the involvement of protein kinase C // Br. J. Pharmacol. 1998. V. 124. Р. 600–606.
30. Jin W., Lee N. M., Loh H. H., Thayer S. A. Opioid mobilize calcium from inositol 1,4,5-triphosphate-sensitive stores in NG108-15 cells // J. Neurosiense. 1994. V. 14. Р. 1920–1929.
31. Periyasamy S., Hoss W. Kappa opioid receptors stimulate phosphoinositide turnover in rat brain // Life Sci. 1990. V. 47. Р. 219–225.
32. Sheng J. Z., Wong N. S., Tai K. K., Wong T. M. Lithium attenuates the effects of dynorphin (A1-13) on inosotol 1,4,5-triphosphate and intracellular Ca2+ in rat ventricular myocytes // Life Sci. 1996. V. 59. Р. 2181–2186.
33. Ventura C., Lokatta E.G., Sisini A. et al. Leucine- enkephalin increases the level of inositol (1,4,5) triphosphate and releases calcium from an intracellular pool in rat ventricular cardiac myocytes // Boll. Soc. Ital. Biol. Sper. 1991. V. 67. № 3. Р. 261–266.
34. Clo C., Muscari C., Tantini B., Pignatti C., Bernardi P., Ventura C. Reduced mechanical activity of perfused rat heart follwoing morphine or enkephalin peptides administration // Life Sci. 1985. V. 37. Р. 1327–1333.
35. Maslov L. N., Lishmanov Yu. B. The anti-arrhythmic effect of D-Ala2,Leu5,Arg6-enkephalin and its possible mechanism // Int. J. Cardiol. 1993. V. 40. № 2. Р. 89–94.
36. Gross R. A., Moises H. C., Uhler M. D., Macdonald R. L. Dynorphin A and cAMP-dependent protein kinase independently regulate calcium currents // Proc. Natl. Acad. Sci. USA. 1990. V. 87. Р. 7025–7029.
37. Kang Y.-M., Zhang C., Qiao J.-T. Involvement of endogenous opioids and ATP-sensitive potassium channels in the mediation of carbachol-induced antinociception at the spinal level: a behavioral study in rats // Brain Res. 1997. V. 761. Р. 342–346.
38. Ocana M., Del Ponzo E., Baeyens J. M. ATP-dependent K+ channel blockers antagonize morphine but not U-50,488H-induced antinociception // Eur. J. Pharmacol. 1993. V. 230. Р. 203–207.
39. Ocana M., Del Ponzo E., Barrios M., Baeyens J. M. Subgroups among ј opioid receptor agonists distinguished by ATP-sensitive K+ channelacting drugs // Br. J. Pharmacol. 1995. V. 114. Р. 1296–1302.
40. Wild K. D., Vanderah T., Mosberg H. I., Porreca F. Opioid ґ receptor subtypes are assiated with different potassium channels // Eur. J. Pharmacol. 1991. V. 193. Р. 135–136.
41. Atwal K. S., Grover G. J. Treatment of myocardial ischemia with ATP-sensitive potassium channel (KATP) openers // Current Pharmaceutical Design. 1996. № 2. Р. 585–595.
42. Gross G. J., Fryer R. M. Sarcolemmal versus mitochondrial ATP-sensitive K+ channels and myocardial preconditioning // Circ. Res. 1999. V. 84. Р. 973–979.
43. Shankar V., Armstead W. M. Opioids contribute to hypoxia-induced pial artery dilation throgh activation of ATP-sensitive K+ channels // Am. J. Physiol. 1995. V. 269. Р. 997–1002.
44. Champion H. C., Kadowitz P. J. D-[Ala2]endomorphin 2 and endomorphin 2 have nitric oxide-dependent vasodilator activity in rats // Am. J. Physiol. 1998. V. 274. Р. 1690–1697.
45. Lishmanov Yu. B., Maslov L. N. Opiatergic regulation of central haemodynamics // Pathol. Physiol. Exp. Ther. 2003. № 1. P. 2–11.
46. Prosekina E. Yu., Tomova T. A. Modulatory effect of leu-enkephalin on gastric secretion using various stimulants // Exp. Clin. Pharmac. 2006. V. 69. № 3. P. 29–31.
47. Prosekina E. Yu., Tomova T. A., Zamoschina T. A. Investigation of the role of M-cholinergic receptors in the realization of the effects of leuenkephalin on gastric secretory function // Exp. Clin. Gastroentherol. 2007. № 1. P. 29–31.
48. Fryer R. M., Wang Y., Hsu A. K., Gross G. J . Essential activation of PKS-ґ in opioid-initiated cardioprotection // Am. J. Physiol. 2001. V. 280. № 3. P. 1346–1353.
49. Lawlor P. G., Gagnon B, Mancini I. L., Pereira J. L., Hanson J., Suarez-Almazor M. E. Occurrence, causes, and outcome of delirium in patients with advanced cancer: a prospective study // Arch. Intern. Med. 2000. V. 160. № 6. Р. 786–94.
50. Maslov L. N., Barzakh E. I., Winged A. V., Chernysheva G. A., Krieg T. Solenkova N. V., Lishmanov A. Yu. et al. Opiod peptide deltorfin 2 mimics cardioprotective effect of ischemic preconditioning: role of delta 2-opioid receptor, protein kinase C, KATP-Channels // Bull. Experim. Biol. med. 2010. V. 149. № 3. P. 524–543.
51. Peart J. N., Gross E. R., Gross G. J. Effect of exogenous kappa-opioid receptor activation in rat model of myocardial infarction // J. Cardiovasc. Pharmacol. 2004. V. 43. № 3. P. 410–415.
52. Vlasova I. G., Torshin V. I. Antihypoxia properties of opiates and substance P // Pathol. Physiol. Experimental. Ther. 2001. №. 3. P. 13–15.
53. Andrzej Rubaj., Katarzyna Gustaw., Witold Zgodzinski, Zdzislaw Kleinrok., Maria Sieklucka-Dziuba. The role of opioid receptors in hypoxic preconditioning against seizures in brain // Pharmacol., Biochem. Behavior. 2000. V. 67. P. 65–70.
54. Howman Sonia, Groeger Jeffrey. Endogenous opioids and hypoxic survival // Crit. Care Med. 1999. V. 27. № 9. P. 2057–2058.
55. Karash Yu. M., Strelkov R. B., Chizhov A. Ya. Normobaric Hypoxia Treatment, Prevention and Rehabilitation. M.: Medicine, 1988. 352 p.
56. Zabornyj T., Gonzales G. F., Valdez L. B. Mitochondrial contribution to the molecular mechanism of heart acclimatization to chronic hypoxia: role of nitric oxide // Frontiers in Bioscience. 2007. V. 12. № 1. P. 1247–1259.
57. Lishmanov J. B., Uskina E. V., Maslov L. N., Winged A. V. Opiatergicheskie mechanisms of antiarrhythmic effect of adaptation // Bull. Experim. Biol. Med. 1996. № 9. Р. 276–278.
58. Kolar F., Ostadal B. Molecular mechanisms of cardiac protection by adaptation to chronic hypoxia // Physiol. Res. 2004. V. 53. Р. 3–13.
59. Xue-Quin Chen, Ji-Zeng Du. Hypoxia influenses enkephalin release in rats // Neuropsyiol. 2000. V. 11. № 7. P. 1555–1557.
60. Lishmanov Yu. B., Maslov L. N., Tam S., Bogomaz S. A. Opioid system and the stability of the heart to injury during ischemia-reperfusion // Ros. Physiol. J. 2000. V. 86. № 2. P. 164–173.
61. Daphne M. Bofetiado, Kimberly P. Maifield, Louis G. D Alecy Alkaloid ґ agonist BW373U86 increase hypoxic tolerance // Anesth. Analg. 1996. V. 82. P. 1237–1241.
62. Endoh Hiroshi, Taga Kichiro,Yamakura Tomohiro, Sato Kazunori, Watanabe Ippei, Fukuda Satory. Effects of naloxone and morphine on acute hypoxic survival in mice // Crit. Care Med. 1999. V. 27. № 9. P. 1929–1933.
63. Meng Fanjun, Li Junfa, Zhang Bingxi, Ji Fang. nPKCµ and NMDA receptors participate in neuroprotection induced by morphine pretreatment // J. Neurosurg. Anestesiol. 2006. V. 18. № 2. P. 119–124.
64. Zakusov V. V., Yasnetsov V. V., Ostrovskaya R. U., Motin V. G. Effect of agonists and antagonists of opiate receptors in the resistance to hypoxyc hypoxia // Byll. Experim. Biol. med. 1984. V. 98. № 12. P. 680–682.
65. Zoloyev G. K., Argintaev E. S., Bobrov I. V., Shilnikov M. G., Pavlenko V. S., Abisova N. A. The value of mu-and delta-opioid receptors in the realization of the effect of enkephalins to the action of hypoxia // Bull. Experim. Biol. Med. 1992. V. 114. № 11. P. 500–502.
66. Kimberly P. Maifield, Louis G. D. Role of endogenous opioid peptides in the acute adaptation to hypoxia // Brain. Res. 1992. V. 582. P. 226–231.
67. Kimberly P. Maifield, Louis G. D. Delta-1 opioid receptor dependence of acute hypoxic adaptation // J. Pharm. Exp. Ther. 1993. V. 269. № 1. P. 74–77.
68. Y unhui Zhang, Hong Qian, Peng Zhao, Soon-Sun Hong, Ying Xia. Rapid hypoxia preconditioning protects cortical neurons from glutamate toxicity through ґ-opioid receptor // Stroke. 2006. V. 37. P. 1094–1099.
69. Mayfeld K. P., Kozak W., Malvin G. M., Porreca F. Hypoxia decreased opioid delta receptor expression in mouse brain // Neuroscience. 1996. V. 72. № 3. P. 785–789.
Выпуск: 8, 2011
Серия выпуска: Выпуск № 8
Рубрика: Biology
Страницы: 109 — 114
Скачиваний: 962